Increased Genome Instability in Aging Yeast
نویسندگان
چکیده
In the September 26 issue of Science, McMurray and Gottschling (2003) report that aged yeast cells display high rates of loss of heterozygosity. Furthermore, they show that this reflects an impaired ability to correctly detect and repair DNA double-strand breaks. These results provide insights into how aging can engender genomic instability in eukaryotic cells.
منابع مشابه
Increased genome instability is not accompanied by sensitivity to DNA damaging agents in aged yeast cells.
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عنوان ژورنال:
- Cell
دوره 115 شماره
صفحات -
تاریخ انتشار 2003